TSATSANIS Christos | International Program in Medicine

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2810.39.4833 (Office)

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Professor of Clinical Chemistry, Director of the Laboratory of Clinical Chemistry-Biochemistry at the University Hospital of Heraklio, Affiliated Researcher at IMBB-FORTH

Education

1991: BSc in Biology, National Kapodistrian University of Athens, Greece

1995: PhD, University of Crete, Greece in collaboration with the University of Glasgow, Scotland

1995 – 1998: Postdoctoral Fellow, Fox Chase Cancer Center, Philadelphia, PA, USA

1998 – 1999: Postdoctoral Fellow, Thomas Jefferson University, Philadelphia, PA, USA

2007: Accreditation as Clinical Chemistry specialist (EurClinChem) and European Specialist in Laboratory Medicine (EuSpLM)

6/2008 – 6/2009: Visiting Assistant Professor, TUFTS-New England Medical Center, Boston, MA, USA

8/2016 – 8/2017: Visiting Professor, Dept. of Translational Medicine, School of Medicine, Lund University, Sweden

Research Interests

Our research aims to delineate the molecular mechanisms regulating inflammation and inflammatory diseases and identify biomarkers and therapeutic targets. In this context the lab analyzes mechanisms regulating activation and inactivation of macrophages at the level of signal transduction, cell metabolism and epigenetics. How metabolic changes at the level of organism (obesity, insulin resistance, microbiome) or at the cellular level (expression of signaling regulators or epigenetic modulators) affect innate immune training and alter responses to pathogens or other inflammatory triggers is investigated. The impact of nutrition on shaping innate immune responses and trained immunity is studied. The lab also focuses in the identification of circulating non-coding RNAs as biomarkers of inflammation-related disorders.

Publications

Selected Publications (out of 127):
Vergadi E, Kolliniati O, Lapi I, Ieronymaki E, Lyroni K, Alexaki VI, Diamantaki E, Vaporidi K, Hatzidaki E, Papadaki HA, Galanakis E, Hajishengallis G, Chavakis T, Tsatsanis C. (2024) An IL-10/DEL-1 axis supports granulopoiesis and survival from sepsis in early life. Nat. Commun. 15:680.

Kolliniati O, Ieronymaki E, Vergadi E, Tsatsanis C. (2022) Metabolic Regulation of Macrophage Activation. J Innate Immun. 14:51-68.

Ieronymaki E, Theodorakis EM, Lyroni K, Vergadi E, Lagoudaki E, Al-Qahtani A, Aznaourova M, Neofotistou-Themeli E, Eliopoulos AG, Vaporidi K, Tsatsanis C. (2019) Insulin Resistance in Macrophages Alters Their Metabolism and Promotes an M2-Like Phenotype. J Immunol. 202:1786-1797.

Arranz A, Doxaki C, Vergadi E, Martinez de la Torre Y, Vaporidi K, Lagoudaki ED, Ieronymaki E, Androulidaki A, Venihaki M, Margioris AN, Stathopoulos EN, Tsichlis PN, Tsatsanis C. (2012) Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization. Proc Natl Acad Sci U S A. 109:9517-22.

Androulidaki A, Iliopoulos D, Arranz A, Doxaki C, Schworer S, Zacharioudaki V, Margioris AN, Tsichlis PN, Tsatsanis C. (2009) The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity 31:220-31.

Complete list of publications can be found at:
https://scholar.google.gr/citations?hl=en&pli=1&user=KKvCaPkAAAAJ
and
https://www.ncbi.nlm.nih.gov/pubmed/?term=tsatsanis+c

Memberships

Board Member and head of the Scientific Committee of the Greek Society of Clinical Chemistry-Biochemistry
Representative of Greece at the European Federation of Laboratory Medicine (EFLM)
Member of the Congresses and Conferences Committee of the International Federation for Clinical Chemistry and Laboratory Medicine (IFCC)
Associate Editor, Journal of Immunology, American Association of Immunology, (2014-2018, 2 terms)
Associate Editor, Frontiers in Immunology (2023-present)

University of Crete

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